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Even a single 8-hour temperature excursion at room temperature (2025C) accelerates oxidation enough to compromise 3050% of methionine residues

In lean women with PCOS, whose insulin resistance is less weight-dependent, the expected benefit is more uncertain and would rest more heavily on the direct islet and hepatic effects that have not been separately quantified

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For example, it is known that frequent use of the drug group known as NSAIDs causes stomach damage and may cause problems such as reflux, gastritis and ulcers